Guillain-Barré syndrome (GBS) is an autoimmune disease that damages the nerves of the peripheral nervous system, causing paralysis in humans.
Zika Virus Infection: A Possible Cause in the Development of Guillain-Barré Syndrome?
Novel Circulating Exosomal microRNAs for Early Diagnosis and Prognosis of HCV-Associated Liver Diseases
Liver cancers are a major global burden accounting for approximately 782,000 deaths annually. Amongst the various risk factors, hepatitis C virus (HCV) is thought to be responsible for 25% of liver cancers resulting in 350-500,000 deaths annually.
Herpes simplex virus 1 in oncolytic virotherapy for treatment of triple negative breast cancer
Breast cancer is the leading cause of death in women under 40, with triple negative breast cancer (TNBC) being the most aggressive form of the disease with the poorest overall survival rates of all breast cancer types.
Solving the Paradox: Deciphering HIV-I Persistence in Hematopoietic Stem
Opposing the common interferon-stimulated antiviral mechanisms employed by terminally differentiated cells, a recent study revealed that stem cells constitutively express critical subsets of interferon stimulated genes (ISGs) that confer effective protection against viral infection.
Towards the Long-Term Protection for Prostate Cancer
Worldwide, prostate cancer (PC) is the second most commonly diagnosed cancer in men, and the second leading cause of cancer death in the developed world [1-4]. Approximately 11% of all men in the United States are diagnosed with PC over their lifetime, with the incidence increasing with age .
Using Wolbachia infected mosquitos to combat arboviral transmission: from molecular mechanisms to global application
The global disease burden inflicted by arboviruses such as dengue, Zika, and chikungunya viruses represents a pressing public health crisis.
CRISPR/Cas13a as a viral nucleic acid detection mechanism for POC testing
Until the development of the CRISPR-based platforms, SHERLOCK and DETECTR, no molecular diagnostic technique existed that is accurate, fast (i.e. detection within a few hours), inexpensive and portable.
Use of combinational broad-spectrum antiviral cocktail for treating current and emerging coronavirus infections
Coronaviruses pose a serious threat to the human population due to the high mortality rate of some strains such as SARS-CoV and MERS-CoV, and also the circulation of other zoonotic strains that may one day infect the human population.
A CRISPR-Cas13 system based diagnostic tool for arboviruses
The unpredictability of the emergence and re-emergence of arboviruses underscores the need for enhancing global preparedness in surveillance capacity for tracking and predicting the growth of arboviral epidemics and case-specific arboviral disease management.
Human Cytomegalovirus: The Implications of MicroRNAs in Latency and Therapeutics
Human cytomegalovirus (HCMV) infects the majority of the world’s population. Primary infection is generally asymptomatic in healthy individuals and as with all herpesviruses, a lifelong latency associated with periodical reactivations is established.